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A treat-to-target approach for GI involvement would require validated motility testing, biomarker development, microbiome profiling, robust patient-reported outcomes, and integration with digital symptom tracking

Approval in another country does not mean it is legal to use as a drug in the U.S

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The Wnt/-catenin pathway also plays a key role in autoimmunity as observed in rheumatoid arthritis (76, 77) and in response to bacterial infections and inflammation (78, 79)